It has a citrusy, zesty aroma that features in lots of fragrances and can possibly help lift your spirits.

In another study, the combination of BP and UVA was found to induce melanogenesis in S91 murine melanoma cells and normal human melanocytes [ 44]. The melanogenesis induced by the combined effects of BP and UVA was associated with an increase in the expression of tyrosinase. In normal melanocytes but not in murine melanoma cells, melanogenesis and DOPAchrome tautomerase (DCT) activity were negatively correlated, suggesting that the treatment induces the metabolic pathway of dark eumelanin with a high protective capacity against UV rays. 4.4. Anticancer Osteoporosis, also called “fragile bone disease,” is characterized by a decrease in bone density, generated by a demineralization process, by the loss of calcium and phosphorus in the bone [ 53, 54]. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet: “Effect of Inhaling Bergamot Oil on Depression-Related Behaviors in Chronic Stressed Rats.” Citrus bergamia, the bergamot orange (pronounced / ˈ b ɜːr ɡ ə m ɒ t/), is a fragrant citrus fruit the size of an orange, with a yellow or green colour similar to a lime, depending on ripeness.After the initial hour, the amber and musk notes emerge more and balance the fragrance. It still has that bright, citrusy behavior, but I get more intense undertones of floral notes and musky herb-based spice. At times, it can feel quite powdery and slightly soapy. The amber is akin to ambergris, more salty that sweet. Either put a few drops of bergamot oil in a diffuser and breathe in the scent or rub some on your chest, providing it’s been blended with a carrier oil first. As is the case with all essential oils, never apply neat bergamot oil to your skin because it can cause adverse reactions. Similar results were obtained by Hönigsmann et al. [ 62], in a study carried out using psoriatic and nonpsoriatic subjects (Honigsmann, 1979 #17). In this clinical trial, the used doses of BP did not cause the adverse effects related to 8-MOP such as erythema, blistering, and pruritus [ 62] (Honigsmann, 1979 #17). BP also showed a notable effectiveness and tolerance in the photochemotherapy of mycosis fungoides either alone or in combination with retinoic acid [ 35]. The authors declare that there are no conflict of interests regarding the publication of this paper. Authors’ Contributions

Sun sensitivity. Bergamot oil may be less safe as a skin treatment since it can make your skin more sensitive to sunlight. It may also be unsafe as a skin treatment for people who are pregnant or breastfeeding. Bergamot plants produce flowers that have an extremely distinctive look about them. The flower heads consist of several tubular flowers that grow from the centre, creating a shaggy dome of petals. Bergamot flowers appear from early summer right through to early autumn. 5 What does bergamot smell like? In this comprehensive review, the literature on the biological properties of bergapten was collected, analyzed, and summarized. Scientific search engines such as PubMed, ScienceDirect, and Google Scholar have been used to collect all published articles on this bioactive compound. Several MESH terms have been used as keywords such as “5-Methoxypsoralen”, “Anti-Inflammatory Agents”, “Humans”, “Methoxsalen”, “Osteoporosis”, “Animals”, “Bone Resorption / prevention & control”, “Diabetes Complications”, “Disease Models”, “Animal”, “Methoxsalen /adverse effects”, “Methoxsalen/pharmacokinetics”, “Biological Availability”, and “Clinical Trials as Topic”. All significant papers published on bergapten in English have been cited in this study. The identification and examination of the collected manuscripts were based on their titles and abstracts. The reference lists of the works taken over were also examined to identify other relevant works. The scientific names of the plants have been validated according to Plant List [ 13, 14]. 3. Bioavailability of Bergapten The open-field test is considered as an indicator of the emotional state of the animal, which allows an easy and fairly rapid assessment of well-defined behaviours, such as crossing, wall rearing, grooming, center, and immobility, and it is widely used in the screening of drugs that act on the central nervous system (CNS) [ 27]. Particularly, crossing and wall rearing can be, respectively, regarded as indicators of locomotor activity and exploratory behaviour, whereas grooming, center, and immobility are behaviours positively correlated with fear or emotionality [ 27– 29]. The rat was placed in the center of a dark plastic circular arena (75 cm diameter) in a sound proof room with 20 lux light [ 27]. The duration of each behavioural session was 20 min. The assessed parameters (general locomotor activity in an interval of 5 min (square limit crossings with both forepaws and wall rearing), anxiety-related behaviour (face and body grooming, head washing, and time spent in the center of arena), and immobility) were videotaped and analyzed to be scored (Labehaviour). 2.5. Statistics

 Jo Malone perfume dupes

When applied topically, bergamot oil should be diluted with a cold-pressed carrier oil that ideally contains no more than 0.4% bergamot due to its potential side effects. 20 Remember how we mentioned to you about bergamot’s aroma being zesty, floral and well, just fresh? When you diffuse bergamot or combine it with a carrier oil and rub it into your skin, the citrusy, uplifting burst of freshness it gives off can really help perk you up! Servillo, Luigi; Giovane, Alfonso; Balestrieri, Maria Luisa; Casale, Rosario; Castaldo, Domenico (2013-05-17). "Citrus genus plants contain N-methylated tryptamine derivatives and their 5-hydroxylated forms". Journal of Agricultural and Food Chemistry. 61 (21): 5156–5162. doi: 10.1021/jf401448q. ISSN 1520-5118. PMID 23682903.