There are many factors involved in wound healing (Guo and Dipietro, 2010). The healing process is not static and growth involves four different phases, namely coagulation and hemostasis, inflammatory, proliferation, and remodeling. These phases are not independent but partially overlap on the basis of a sequence by hemostasis, inflammatory, proliferation, and remodeling (Kasuya and Tokura, 2014; Wilhelm et al., 2017). After skin injury, the wound or tissue fracture is filled with blood clots, followed by acute inflammation of the surrounding tissue. The release of inflammatory mediators and infiltration of inflammatory cells cause tissue swelling and pain. Proliferative fibroblasts, endothelial cells, and newly formed capillaries interact to form granulation tissue filling the crevices. During the shaping period, the scars are softened without affecting the tensile strength through the action of various enzymes and stress, thereby adapting to physiological functions (Jeffcoate, 2012; Harper et al., 2014; Nuutila et al., 2016; Ascione et al., 2017a, b). Meaume S, et al. Use of a new, flexible lipidocolloid dressing on acute and chronic wounds: results of a clinical study. J Wound Care. 2011;20(4):180,182-5. Palfreyman S., King B., Walsh B. (2007). A review of the treatment for venous leg ulcers. Br. J. Nurs. 16, S6–14. 10.12968/bjon.2007.16.8.23412 [ PubMed] [ CrossRef] [ Google Scholar]

Karlsmark T., Agerslev R. H., Bendz S. H., Larsen J. (2003). Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers. J. Wound Care 12, 351–354. 10.12968/jowc.2003.12.9.26534 [ PubMed] [ CrossRef] [ Google Scholar]UrgoClean® is indicated for sloughy wounds (leg ulcers, pressure ulcers, diabetic, acute or chronic wounds) Acosta J. B., del Barco D. G., Vera D. C., Savigne W., Lopez-Saura P., Guillen Nieto G., et al.. (2008). The pro-inflammatory environment in recalcitrant diabetic foot wounds. Int. Wound J. 5, 530–539. 10.1111/j.1742-481X.2008.00457.x [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

Do not use UrgoClean in combination with hydrogen peroxide, organomercuric antiseptics or hexamidine.

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In the absence of specific clinical data, use in pregnant or breast-feeding women, newborn and premature babies is not recommended. Harding K. G., Krieg T., Eming S. A., Flour M. L. (2005). Efficacy and safety of the freeze-dried cultured human keratinocyte lysate, LyphoDerm 0.9%, in the treatment of hard-to-heal venous leg ulcers. Wound Repair Regen. 13, 138–147. 10.1111/j.1067-1927.2005.130204.x [ PubMed] [ CrossRef] [ Google Scholar] Dawkins H. (2017). Non-healing venous leg ulcer. Br. J. Nurs. 26, S26–S27. 10.12968/bjon.2017.26.Sup20a.S26 [ PubMed] [ CrossRef] [ Google Scholar] Edmonds M, Lázaro-Martínez JL, Alfayate-García JM, Martini J, Petit JM, Rayman G, Lobmann R, Uccioli L, Sauvadet A, Bohbot S, Kerihuel JC, Piaggesi A. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196. NICE Medical Technology Guidance (MTG242): UrgoStart for treating leg ulcers and diabetic foot ulcers; https://www.nice.org.uk, accessed January 2019.

Imran D., Sassoon E., Lewis D. (2004). Protection of dressings and wounds by cling film. Plast. Reconstr. Surg. 113, 1093–1094. 10.1097/01.PRS.0000107737.67371.D7 [ PubMed] [ CrossRef] [ Google Scholar] Modern dressings promoting the healing of VLU. (A) Ulcer areas in patients with infected (red line) and non-infected (blue line) at different time points. (B) Trends in the ulcer area in different patients. (C) Initial state of the wound. (D) Dressing application of cell foam dressing with through holes (ROCF-CC). (E) Dressing replacement. Reproduced with permission from Harding et al. ( 2016) and McElroy et al. ( 2018). Parpex P. et al. Management of venous leg ulcers with Cellosorb® Micro-adherent dressing: results of a multi-centre clinical trial. Phlebologie 2010; 63: 76-82. Münter KC, Meaume S, Augustin M, Senet P, Kérihuel J.C. The reality of routine practice: a pooled data analysis on chronic wounds treated with TLC-NOSF wound dressings. J Wound Care. 2017 Feb; 26 (Sup2): S4-S15. Erratum in: J Wound Care. 2017 Mar 2; 26(3): 153TLC-NOSF: Lipido-Colloid technology – Nano OligaSaccharide Factor (KSOS: Potassium octasulfate sucrose salt). Cutimed Sorbact can be used for all contaminated, colonised and infected, exuding wounds such as pressure, diabetic foot and venous leg ulcers. Also suitable for traumatic and post-operative wounds. Francesko A., Petkova P., Tzanov T. (2017). Hydrogel dressings for advanced wound management. Curr. Med. Chem. 25, 5782–5797. 10.2174/0929867324666170920161246 [ PubMed] [ CrossRef] [ Google Scholar]

UrgoTul Ag/Silver can be cut using sterile scissors to fit the dressing size to the wound if necessary. Hold secondary dressing in place with a conforming bandage, adhesive tape or an elasticated tubular bandage. Clinicians and healthcare professionals must take into account the fact that data concerning the prolonged and repeated use of a silver dressing, particularly in children and newborn babies, is not very extensively documented. Hobot J., Walker M., Newman G., Bowler P. (2008). Effect of hydrofiber wound dressings on bacterial ultrastructure. J. Electron Microsc. 57, 67–75. 10.1093/jmicro/dfn002 [ PubMed] [ CrossRef] [ Google Scholar]

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As it includes a super-absorbent layer, the central pad should not be cut. However, the adhesive edges can be cut if necessary using sterile scissors to fit the dressing to different wound shapes. McElroy E., Lemay S., Reider K., Behnam A. B. (2018). A case review of wound bed preparation in an infected venous leg ulcer utilizing novel reticulated open cell foam dressing with through holes during negative pressure wound therapy with instillation. Cureus 10:e3504. 10.7759/cureus.3504 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Collagen and oxidised regenerated cellulose matrix, applied directly to wound and covered with suitable dressing.