A: We’re working with our suppliers to bring costs down, but at least initially many of the new NAD+ supplements will be more expensive than NMN. That said, they will also be more concentrated so less will be needed to accomplish the same outcome. The price of NMN dropped significantly over the last few years. We expect that with volume and manufacturing innovations costs and prices will come down on our new products too. NMN is a natural metabolite of vitamin B3 and a precursor to NAD+ which supports myriad functions essential to health and healthy aging. NAD+ levels decline in human tissue by at least 50 percent between the ages of 40 and 60. Taking NMN boosts natural NAD+ production, and provides the body with energy for gene repair and stimulation.

One such way to improve your overall health and longevity is nicotinamide mononucleotide, often found in the form of NMN supplements. A Closer Look at NMN (Nicotinamide Mononucleotide) Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.

The ProHealth Promise

Regular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol. Because research suggests that only the trans-form has valuable biological activity, NMN Pro Complete contains pure, natural, pharmaceutical grade trans-resveratrol. Don’t be fooled by copycats. Our Uthever® NMN Pro capsules stand out as a brand you can trust with high-quality products containing purity and potency.

You, Y., Gao, Y., Wang, H., Li, J., Zhang, X., Zhu, Z., & Liu, N. (2020). Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. Frontiers in Pharmacology, 11. NMN and trans-resveratrol work synergistically, which is why longevity experts recommend taking them together for the greatest effectiveness. This dynamic duo has been likened to the operation of a car, with NMN as the fuel and trans-resveratrol as the accelerator pedal. Suggested Use: Take 2 capsules daily, with or without food, preferably in the morning, or as directed by your healthcare practitioner. There are three ways companies approach solving this bioavailability conundrum, and we’ll describe those in detail below in our section on how NMN supplements work. To help you understand how we applied these solutions to our efficacy rating, we’ll say that we prefer as direct an influx of NMN to the bloodstream as possible. Sublingual powders or liquids, dissolving tablets, and nasal sprays are the best delivery mechanisms for sending NMN straight to the bloodstream without involving the GI tract.Suggested Use: Take 2-4 capsules daily, with or without food, preferably in the morning, or as directed by your healthcare practitioner. Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., & Yoshino, J. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795.

NMN supplements haven’t consistently shown any adverse effects in the research. 8 That includes analysis using doses higher than those commonly available. So you can expect to feel only positives as you take NMN. CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product

Jiang, Y., Luo, Z., Gong, Y., Fu, Y., & Luo, Y. (2023). NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling. Oncogene, 42(11), 808-824. While they may be faster-acting, sublingual delivery doesn’t seem to increase long-term bioavailability, at least according to one vitamin B study. 13 And lipid nanocarriers can theoretically protect NMN until it gets to the small intestine, where a dedicated NMN transporter is waiting to help you absorb it. But there’s more than one type of liposomal delivery system, and each will act differently in delivering specific elements or compounds. 14 Ultimately, we need more data to conclude whether elevated NAD levels pose a cancer risk. Both of these things may be true: In addition to that real-world experience with NMN, our team has pored over dozens of scientific journal articles devoted to NAD production and NMN metabolism. All of this preparation allows us to confidently suggest which available supplements stand the best chance of increasing your NAD levels.