IPL increased the molecular weights of lysozyme, lactoferrin, and albumin as well as the concentrations of total lipids, triglycerides, cholesterol, and phospholipids in tear fluid If you have a plate warming setting on your oven, use that. If not, set your oven to the lowest temperature which should be 50 to 60 degrees C. Monocular VTP improved the number of functional MGs and symptoms compared with the control eye for up to 3months

Badawi D. TearCare® system extension study: Evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare ® treatment on subjects with dry eye disease. Clin Ophthalmol. 2019;13:189–98. STEP 2: Shake the Blepha EyeBag® to evenly spread the linseeds inside the mask and to help the heat to spread. Severity of baseline symptoms and male gender were associated with symptomatic improvement after VTP Bäumler W, Vural E, Landthaler M, Muzzi F, Shafirstein G. The effects of intense pulsed light (IPL) on blood vessels investigated by mathematical modeling. Lasers Surg Med. 2007;39(2):132–9. Twenty-five participants completed the study (mean age 38±15 years, 7 male). There was a significant change in OSDI over time for the EyeBag group (mean[lower 95% CI, upper 95% CI], baseline: 39.1[31.1,47.0], 2wk: 26.8[19.7,33.9], 4wk: 26.6[16.5,36.7], 8wk: 27.7[18.4,37.0]; p=0.01), but not in the control group (p=0.22), but no significant difference between groups at all time points (all p>0.27). Symptoms immediately improved after conducting the EyeBag based on at-home CSQ scores (Δ=-5.0 points, p<0.01), but not in the control group. For both groups, there was no significant change (p-value EyeBag,p-value control) in MG score (0.21,0.17) and NIBUT (0.49,0.06) over time.In both dry eye and blepharitis, the glands that secrete oily moisture to the surface of the eyes are clogged and inflamed. This is known as meibomian gland dysfunction, or MGD. VTP increased TBUT and the number of functional MGs as well as reduced ocular symptoms for up to 3months DO NOT HEAT IN ANY TYPE OF IMPLEMENT THAT MIGHT CAUSE THE EYEBAG TO BE SET ON FIRE. DO NOT THEREFORE HEAT IN A BARBECUE, GRILL, FONDUE, CHIMINEA, BOILING PAN, CHARGRILL, PANINI MAKER, TOASTER, TOASTED SANDWICH MACHINE, DEEP FAT FRYER, CHIP PAN, OPEN FIRE, COAL EFFECT GAS FIRE, ELECTRIC BAR FIRE, HALOGEN HEATER, SPIT ROAST, BLOW TORCH. THIS LIST IS NOT EXHAUSTIVE.

Jiang X, Lv H, Song H et al. Evaluation of the safety and effectiveness of intense pulsed light in the treatment of meibomian gland dysfunction. J Ophthalmol. 2016

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The Blepha EyeBag (formally MGDRx® EyeBag®) is a patented, CE marked Class 1 medical device registered with the Medicines and Healthcare products Regulatory Agency (MHRA). It was devised by a UK ophthalmologist to help his dry eye patients. VTP improved the number of functional MGs and symptoms and was as effective as lid hygiene practised twice daily for 3months The EyeBag ® Instant (The Eyebag Company, Halifax, UK) is a single-use, disposable warm compress. It is activated by air; therefore, it starts to heat 2–3 min after the mask is removed from the sachet, and it can be placed on the eyelids for 10 min [ 20].

MGD is the main cause of evaporative dry eye disease (DED), the most prevalent type of DED. Additionally, MGD is present in some cases of aqueous-deficiency DED [ 2]. DED is an ocular surface anomaly whose prevalence ranges from 5 to 50% worldwide, and it is associated with limitations in performing activities of daily life and even sometimes with depression [ 6, 7]. Therefore, it is important to properly manage MGD. Delays also often occur at Easter because the depots are shut on Easter Monday & Good Friday and hence post builds up. Bilkhu PS, Naroo SA, Wolffsohn JS. Effect of a commercially available warm compress on eyelid temperature and tear film in healthy eyes. Optom Vis Sci. 2014;91(2):163–70. Some studies compared LipiFlow ® with other MGD management strategies. Almost all of the studies comparing the LipiFlow ® with traditional eyelid hygiene (I and III) found an improvement in symptoms in the LipiFlow ® group [ 37, 38, 39, 40]. Only two studies (III) found an improvement in signs, such as MG secretion and BUT [ 39, 41]. Other authors compared LipiFlow ® with other medical devices, such as Tauber et al. [ 42] (I), who compared LipiFlow ® with iLux ® and did not find differences between the two treatments. Another study (II) reported that one single LipiFlow ® session was more effective in decreasing DED symptoms compared to 3 months of oral doxycycline [ 43]. Finally, Yeo et al. [ 44] (I) showed a significant reduction in the tear evaporation rate after 4 and 12 weeks of LipiFlow ® treatment, in contrast to EyeGiene ® and Blephasteam ®. Gibbons A, Waren D, Yesilirmak N, et al. Ocular surface parameters predicting patient satisfaction after a single vectored thermal pulsation procedure for management of symptomatic meibomian gland dysfunction. Cornea. 2017;36(6):679–83.Visual acuity: best corrected monocular and binocular visual acuity was measured using a digital logMAR chart at 6 m, randomised between presentations (Test Chart 2000; Thomson Software Solutions, London, UK). Visual acuity was determined using letter by letter scoring with each letter corresponding to −0.02 logMAR units. Li D, Bin LS, Cheng B. Intense pulsed light: from the past to the future. Photomed Laser Surg. 2016;34:435–47 (Mary Ann Liebert Inc.). Probing improved subjective symptoms, meibum grade, TBUT, lid margin abnormalities, and fluorescein staining compared with the control With Théa’s research and development experience and distribution network of more than 70 countries, the company suggested its platform would be “ideal” to introduce The EyeBag to a global audience. Doctor Krawitz is the original founder of Visivite Eye Vitamins and served as President and C.E.O. of Vitamin Science, Inc. from 2001-2022.

Probing improved ocular symptoms (OSDI) and TBUT for up to 3months as well as reduced hyperaemia and lid margin vascularity Several studies evaluated the IPL treatment along with other treatments. Piyacomn et al. [ 70] (I) observed a higher and faster improvement in the MG function in patients who combined conventional eyelid hygiene and IPL than in those patients who performed hygiene alone. Huang et al. [ 72] (I) compared IPL with intraductal MG probing. They reported that the combination of both methods was more effective than separately in improving symptoms, BUT, meibum grade, and telangiectasias. IPL alone was more suitable for relieving intraductal inflammation, while MG probing was better for patients with severe MG obstruction or MG scarring. Some studies combined IPL treatment with MG expression. While Toyos et al. [ 77] (II) only found an improvement in symptoms and BUT, Dell et al. [ 78] (III) also observed improvements in MG score and corneal staining. However, Arita et al. [ 79] conducted a randomized clinical trial (I) comparing a combined therapy and MG expression alone. They found an improvement in the symptoms, NIBUT, BUT, and MG score in both therapies. However, the improvement was higher after the combined therapy, and this group also improved the LLT and corneal staining. The intense pulsed light (IPL) devices are high-intensity, non-coherent, and non-laser light sources ranging from 500 to 1200 nm [ 61]. Patients are fitted with safety goggles covering both eyes during the treatment. The skin treatment area requires an ultrasound gel. Light pulses are applied into the cheek skin, near the lower eyelids. However, one study (I) evaluated the technique applying pulses directly into the upper eyelids [ 62]. A higher improvement in MG secretion function was found in the lower eyelids than in the upper eyelids. This was attributed to the smaller tear meniscus present in the upper eyelids, which contains fewer inflammatory proteins. Badawi D. A novel system, TearCare®, for the treatment of the signs and symptoms of dry eye disease. Clin Ophthalmol. 2018;12:683–94. Jester J.V., Nicolaides N., Kiss-Palvolgyi I., Smith R.E. Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Investigative Ophthalmology & Visual Science. 1989;30:936–945.

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Furthermore, a statistically significant improvement in ocular symptoms was also observed in test eyes only. Surprisingly, the improvement in ocular comfort scores was observed as early as the evening of treatment Day 1, suggesting that the eyebag produces an increase in ocular comfort for at least 12h following single use. Although subjects still had raised ocular comfort at around 6months after the trial, comfort was maintained best in those who continued treatment 1–8 times a month. It should be noted that subjects were not masked and, therefore, some placebo effect could be possible, although the effect was marked and occurred in all subjects. Eyelid warming therapy associated with eyelid massage has been suggested to induce corneal deformation due to increases in corneal temperature, and with concurrent massaging, possible ectasia. 24 Only one case of corneal deformation following such treatment has been reported, but the duration of treatment in this case was far longer (15min twice a day for 7weeks) than that prescribed herein. Transient visual degradation without changes in corneal topography has been observed after warm compresses (45°C) were applied every 2min for 30min without massage, 25 but again the duration of treatment and peak temperature was sustained for longer than the present study and the treatment method is not typically advised to MGD patients. Therefore, it appears that corneal deformation and/or visual changes, may only occur following unusually long and intense treatment application durations and long-term therapy associated with eyelid rubbing. Caution:If your microwave is greater than 1000w, you may need to reduce the time. How often should the EyeBag be used?