Model 4 – attached to an IBM 1130 minicomputer via the storage access channel (SAC). The 1130 could run either as a standalone processor or as a front-end processor connected to a remote System/360. Ferguson ND, Frutos-Vivar F, Esteban A, et al. Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study. Crit Care. 2007;11(5):R96. Kemnitz K, Yoshihara K (1991) Entropy-driven dimerization of xanthene dyes in nonpolar solution and temperature-dependent fluorescence decay of dimers. J Phys Chem 95:6095–6104 Liu H. L., Chang L. N., Bai C. H., Chen L. Y., Luque R., Li Y. W., Angew. Chem. Int. Ed., 2016, 55, 5019

Zhang W. L., Ji W. L., Li L. J., Qin P. S., Khalil I. E., Gu Z. D., Wang P., Li H. F., Fan Y., Ren Z., Shen Y., Zhang W. N., Fu Y., Huo F. W., ACS Appl. Mater. Interfaces, 2020, 12, 52660

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IBM System/360 Component Description IBM 2250 Display Unit Model 2 IBM 2840 Display Control Model 1 GA27-2702-0. Zhao M. T., Yuan K., Wang Y., Li G. D., Guo J., Gu L., Hu W. P., Zhao H. J., Tang Z. Y., Nature, 2016, 539, 76 Langer G, Bouchal K-D, Grün H, Burgholzer P, Berer T (2013) Two-photon absorption-induced photoacoustic imaging of rhodamine B dyed polyethylene spheres using a femtosecond laser. Opt Express 21:22410–22422

Ma Y-XZR-B, Guo J, Liu Y-S, Yuan M, Bai Z-J, Liu T-T, Zhao X-M, Zhang F (2015) A facile method for studying interaction of rhodamine B and bovine serum albumin: towards physical-binding mediated fluorescence labeling of proteins. Nucl Sci Tech 26:60502 In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients on MV are not treated in ICUs. There are insufficient epidemiological data on these patients. Here, we sought to describe the epidemiology of patients on MV in Japan by comparing and contrasting patients on MV treated in ICUs and in non-ICU settings. A preliminary comparison of patient outcomes between ICU and non-ICU patients was a secondary objective. Methods A reduction of the transcriptional activity of NF‐κB was apparent in both Panc Tul and BxPC3 cell lines by the change in expression of cyclin D1 and Bcl2. This is testimony to the functional relevance of NF‐kB inhibition by GP‐2250. The expression of cyclin D1, the driver of cell cycle progression, was reduced by GP‐2250 (Figure 5). This finding is in line with the previously shown reduction of the rate of cell proliferation by GP‐2250. 1 The expression of the anti‐apoptotic protein Bcl2 was likewise reduced by GP‐2250 (Figure 6). Thus, by inhibiting NF‐κB, GP‐2250 is able to disrupt tumour progression in a two‐pronged manner, by reducing the rate of cell proliferation and promoting apoptosis. Liu L. L., Zhou X. J., Guo L. X., Yan S. J., Li Y. J., Jiang S., Tai X. S., Rsc Adv., 2020, 10, 33417

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Chang G. G., Ma X. C., Zhang Y. X., Wang L. Y., Tian G., Liu J. W., Wu J., Hu Z. Y., Yang X. Y., Chen B. L., Adv. Mater., 2019, 31, 1904969 Kallen AJ, Patel PR, OGrady NP. Preventing catheter-related bloodstream infections outside the intensive care unit: expanding prevention to new settings. Clin Infect Dis. 2010;51(3):335–41. Li L. Y., Li Z. X., Yang W. J., Huang Y. M., Huang G., Guan Q. Q., Dong Y. M., Lu J. L., Yu S. H., Jiang H. L., Chem, 2021, 7, 686 Give it a try now with a similar division by 3. What is the Quotient and Remainder of 2250 Divided by 3? Here we provide you with the result of the division with remainder, also known as Euclidean division, including the terms in a nutshell:

Duke GJ, Barker A, Rasekaba T, et al. Development and validation of the critical care outcome prediction equation, version 4. Crit Care Resusc. 2013;15:191–7. Liu L. M., Chen Z. J., Wang J. J., Zhang D. L., Zhu Y. H., Ling S. L., Huang K. W., Belmabkhout Y., Adil K., Zhang Y., Slater B., Eddaoudi M., Han Y., Nat. Chem., 2019, 11, 622Both HK2 and GAPDH are upregulated in many human tumours and serve as drug targets. 8 Inhibitors of HK2 such as benitrobenrazide show anticancer activity as demonstrated in tumour xenograft models 29 and clinical trials have started with the HK2 inhibitor lonidamine. 8 Apart from limiting glycolysis, HK2 inhibition is expected to contribute to the rise of ROS by reducing the synthesis of the reducing agent NADPH through inhibition of the pentose phosphate pathway. 5, 30 Quartin AA, Campos MA, Maldonado DA, et al. Acute lung injury outside of the ICU: incidence in respiratory isolation on a general ward. Chest. 2009;135(2):261–8. Han B., Li T. B., Zhang J. Y., Zeng C. B., Matsumoto H., Su Y., Qiao B. T., Zhang T., Chem. Commun., 2020, 56, 4870 Zhang W. L., Shi W. X., Ji W. L., Wu H. B., Gu Z. D., Wang P., Li X. H., Qin P. S., Zhang J., Fan Y., Wu T. Y., Fu Y., Zhang W. N., Huo F. W., ACS Catal., 2020, 10, 5805 Zhang W. N., Lu G., Cui C. L., Liu Y. Y., Li S. Z., Yan W. J., Xing C., Chi Y. R., Yang Y. H., Huo F. W., Adv. Mater., 2014, 26, 4056