High levels of pro-oxidants such as polyunsaturated fatty acids, transition metals and a high metabolic rate make the brain particularly sensitive to oxidative stress (Praticò, 2008; Simpson et al., 2015). In the brain, pro-oxidants are relatively abundant compared to the levels of antioxidants, such as glutathione peroxidase (GPx) and catalase (CAT), further exacerbating the brain’s vulnerability to oxidative damage (Praticò, 2008; Simpson et al., 2015). In the aging body, protective mechanisms used to combat oxidative stress are even further compromised because of increased free radical proliferation and decreased antioxidant levels (Junqueira et al., 2004; Stough et al., 2012). CoQ10 offers a wide enough variety of benefits that nearly everyone could find something it could improve in their lives. The question becomes whether the improvements are genuinely needed. People deficient in CoQ10 obviously have the most to gain, but benefits for heart health are among the most common reasons people look to CoQ10. Petersen R. C., Thomas R. G., Grundman M., Bennett D., Doody R., Ferris S., et al. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl. J. Med. 352, 2379–2388. 10.1056/NEJMoa050151 [ PubMed] [ CrossRef] [ Google Scholar] CoQ10 decreased liver enzymes ( AST and GGT) and markers of inflammation in a 12-week study of 41 people with this non-alcoholic fatty liver disease (NAFLD) [ 57]. 12) Amenorrhea

Significantly reduced cardiovascular mortality, confirmed not at intervention but during 10-year follow-upBeal M. F. (1999). Coenzyme Q 10 administration and its potential for treatment of neurodegenerative diseases. Biofactors 9, 261–266. 10.1002/biof.5520090222 [ PubMed] [ CrossRef] [ Google Scholar] Nootropics Depot was the next closest competitor in the safety space thanks to a similar quality of internal testing that Bluebonnet uses and the fact that its CoQ10 contains no other ingredients. But as a powder, there is a greater risk of over- or under-supplementing, and its CoQ10 might degrade in an acidic stomach environment before reaching the small intestine. Convenience and customer service Pandit, S., Biswas, S., Jana, U., De, R. K., Mukhopadhyay, S. C., & Biswas, T. K. (2016). Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers. Andrologia, 48(5), 570–575. CoQ significantly reduced blood sugar in two meta-analyses of 32 trials. Ubiquinol likely has the same effect, but further research is needed to confirm this [ 44, 45]. 5) Chronic Fatigue Syndrome

Zeng, Z. Y., et al. (2018). Efficacy of CoQ10 as supplementation for migraine: A meta‐analysis [Abstract]. Only one study has investigated the neurocognitive effects of CoQ 10 in individuals free from neurodegenerative disease. In this trial, the effects of an acute dosage of 100 mg of CoQ 10 on quantified EEG (QEEG) was examined in 40–55-year-old hypertensive subjects (Marincola, 1997). In this study, the profile of resting QEEG following CoQ 10 administration was similar to that of a cognitive enhancer. It is also interesting to note that in a recent case study by Okeahialam ( 2015) a Nigerian woman with dyslipidemia who had been experiencing statin-induced memory dysfunction, reported resolution of her memory complaints following 4 months of daily CoQ 10 (100 mg/day) supplementation. The participants who took the CoQ10 supplements had significantly reduced statin-related muscle pain. Those who received the placebo reported no change in muscle pain. Another study in 15 healthy active people found that ubiquinol did not improve the athletic performance of the group as a whole. However, further analysis revealed specific improvements in some people: 4 people were able to run significantly longer on the treadmill and 6 people were able to pedal harder on the bike [ 53].People with advanced heart failure may benefit more from ubiquinol as it is absorbed better than ubiquinone. A study of 7 advanced heart failure patients found that ubiquinol (450 – 900 mg/day) greatly improved heart function and symptoms [ 32]. Fujimoto, S., Kurihara, N., Hirata, K., & Takeda, T. (1993). Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases. The Clinical Investigator, 71(8 Suppl), S162–S166.