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Gilbert and colleagues re-sequenced the Christmas Island rat genome and compared it to reference genomes of living members of the Rattus species. “We then explored how evolutionary divergence from the extant reference genome affected the fraction of the Christmas Island rat genome that could be recovered,” the authors write in the paper. Their analyses show that, even when a high-quality genome is used as a reference (the Norway brown rat), almost five percent of the genome sequence is unrecoverable. In total, 1,661 genes were recoverable, and 26 were completely absent. Several of the missing genes are implicated in the rat’s sense of smell, meaning a “de-extinct” version of the Christmas Island rat would not physiologically process smells in an identical manner to the original rat.
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The team used brown rats, commonly used in lab experiments, as the modern reference species, and found they could reconstruct 95 percent of the Christmas Island rat genome. Since becoming a popular concept in the 1990s, de-extinction efforts have focused on grand animals with mythical stature.Pictured: British mother, 66, found stabbed to death in picture postcard Italy home as police hunt for her missing partner Marvel execs 'discussed swapping Jonathan Majors' Kang character for a Dr. Doom storyline during crisis talks' after the actor was arrested for domestic assault
Clearly, there are a number of ethical and societal considerations surrounding de-extinction. As far as the science is concerned, Gilbert and colleagues’ work emphasizes the requirement for a high-quality genome for the extinct species, should genome editing be utilized as the method of choice. While de-extinction projects continue in different parts of the world, Gilbert is hesitant as to whether it is the most appropriate use of scientific effort and resources. “I love the idea and technology behind rewilding with extinct species. I’m not however sure it’s the best use of money in a world of finite resources, however. There are a lot of living species hanging on that could do with the resources. Of course, if money isn’t an issue, I’m all for it. But I rarely suspect that’s the case,” he concludes. Emmerdale's Eric Pollard reveals he is diagnosed with Parkinson's disease in heartbreaking scenes as he bravely confides in Mandy Dingle Instead of focusing on iconic species like the woolly mammoth or the Tasmanian tiger, a team of paleogeneticists have studied how, using gene editing, they could resurrect the humble Christmas Island rat, which died out around 120 years ago. The View's executive producer Brian Teta squirms live on air as Joy Behar FINALLY reveals the real reason why she was 'fired' from daytime show
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