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NF-κB activation can occur through at least two mechanisms. Following H/R or I/R injury, activation of protein tyrosine kinases, such as c-Src, can mediate the tyrosine phosphorylation of IκBα on Tyr42, leading to the mobilization of NF-κB to the nucleus in the absence of IκBα degradation. In contrast, proinflammatory stimuli, such as LPS and TNF, activate NF-κB through IKK-mediated serine phosphorylation of both IκBα and IκBα, promoting ubiquitin-dependent degradation of IκB. We hypothesized that these two fundamental pathways of NF-κB activation account for the observed stimuli-specific differences seen (i.e., NF-κB activation and inflammatory responses) in the livers of ABKI mice in response to LPS and I/R. Abbott was a supporter of Speaker of the House of Commons John Bercow, and defended him from bullying allegations made by David Leakey. [58] She was re-elected at the snap 2019 general election. You’ve got to go two-footed into a Monday. You can’t be scared. You have to look Monday in the eye and say: ‘Here we go again. It’s another dance.’” Thanks, Tom Davis (“ Sunday with…”, Magazine). That’s my Monday mantra sorted. Milne, Seumas (29 April 2015). "From the archive, 29 April 1985: Ken Livingstone wins fight for Brent East nomination". The Guardian. Archived from the original on 27 December 2016. In her published letter, she had written that prejudice was “similar to racism and the two words are often used as if they are interchangeable”.

John McDonnell, a close ally of Abbott who was shadow chancellor under Jeremy Corbyn’s leadership, when Abbott served as shadow home secretary, said Abbott’s comments were “a terrible mistake”. Osborne, Samuel (28 May 2017). "Diane Abbott refuses to say she 'regrets' calling for IRA to defeat British state". The Independent. Archived from the original on 28 May 2017 . Retrieved 28 May 2017.

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In most boroughs with three or more, the Tories won; in most boroughs with only two, the Tories lost. So it is clear that having a local pact or progressive alliance, makes perfect sense if you want to beat the Tories. Until proportional representation is adopted, parties should encourage local pacts in all elections. Otherwise we will end up with another majority rightwing government, with fewer votes than the combined leftwing opposition. United we win, divided we fall.

High Street Ken (12 January 2011). "Diary: Diane's appetite for losing". The Independent. London. Archived from the original on 6 October 2018 . Retrieved 30 August 2017. McDonnell told LBC that his work in the 1980s with anti-Irish racism meant he could “completely understand” people’s anger. Appearing on Andrew Marr's Sunday morning programme for the BBC on 28May, Abbott's apparent support for the IRA nearly 35 years ago came up, along with some parliamentary votes Marr thought questionable. These included her advocacy of the abolition of "conspiratorial groups" such as MI5 and Special Branch in the late 1980s, both of which she said had been successfully reformed. She defended a vote opposing the proscription of a list of groups, including al-Qaida, on the basis that some of the others had the status of dissidents in their country of origin and Abbott would have voted to ban al-Qaida in isolation. [45] According to Sam Coates in The Times, this appearance was arranged without the consent of Labour's campaign team. [46] Abbott at a rally in Trafalgar Square in 2016 MPs pushing abortion rights in NI". BBC News. 23 July 2008. Archived from the original on 26 June 2018 . Retrieved 16 March 2018.

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While I find Diane’s apology insincere and her “initial draft” excuse laughable, I do hope that she is able to learn from this experience. She is clearly a good person with her heart in the right place. I just hope she is able to open her heart (and eyes) to the suffering of others without having to define it. I would encourage her to visit a Jewish museum or memorial to try and better understand her comments and how hurtful they are. In response, a Labour Party spokesperson said: “The Labour Party rightly expects the highest standards of behaviour from its elected representatives, and has introduced an independent complaints process to investigate cases. a b "Play It Again: Diane Abbott takes up the piano". BBC One. 22 April 2007. Archived from the original on 29 June 2011 . Retrieved 5 January 2012. Hughes, Laura (1 February 2017). "Diane Abbott fails to vote in Brexit Bill debate after going home with a migraine". The Telegraph. Archived from the original on 2 February 2017 . Retrieved 2 February 2017.

Racism “takes many forms, and it is completely undeniable that Jewish people have suffered its monstrous effects… as have Irish people, Travellers and many others”. Abbott had a brief relationship with Jeremy Corbyn, who later became the Labour leader, when he was a councillor in north London in the late 1970s. [138] [139] In 1991, she married David P. Ayensu-Thompson, [140] a Ghanaian architect. They had one son together, James (born October 1991 [19] [10] [141]), before divorcing in 1993. [2] [10] [142] Abbott chose her Conservative MP voting pair, Jonathan Aitken, as her son's godfather. [80] Born in Paddington, to a British-Jamaican family, Abbott attended Harrow County School for Girls before reading History at Newnham College, Cambridge. After joining and leaving the Civil Service, she worked as a reporter for Thames Television and TV-am before becoming a press officer for the Greater London Council. Joining the Labour Party, she was elected to Westminster City Council in 1982 and then as an MP in 1987, being re-elected in every general election since. On the issue of abortion, Abbott has become a vocal " pro-choice" supporter, opposing moves towards changing abortion counselling policy, and reducing the abortion time limit. She resigned from a cross-party group on abortion counselling saying it was no more than a front to push forward an anti-abortion agenda without debate in parliament. [30]One consequence has been the entrenchment of what we now call “identity politics”. As hopes for social change have eroded, many have clung ever more fiercely to their own communities as places of safety and shelter. The more one hunkers down in separate laagers, the more the laager becomes the only way through which to perceive the world, and the bigger one’s race or identity looms in one’s consciousness. Antiracism has come to be more fragmented, more inward looking and viewed more as a kind of zero-sum struggle in which the interests of one group are set off against those of another. O'Leary, Naomi (1 May 2012). "Diane Abbott – 'Cambridge was the making of me' ". The Cambridge Student. Archived from the original on 14 July 2014.

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